To What Extent Should Proteinuria Be Reduced

To What Extent Should Proteinuria Be ReducedExcessive urinary protein is a common problem in most kidney diseases and one of the main reasons for the progression of kidney disease to uremia. Today we're going to talk about several common kidney diseases. To what extent should proteinuria be reduced?

1. Minimal change disease, membranous nephropathy stage 1, mild mesangial proliferative nephropathy and purpura nephritis

In these kidney diseases, the damage of immune complex is not so significant, the pathological changes are mild, the renal tissue structure is not obviously damaged, and the 24-hour urinary protein quantity can be reduced to normal (less than 0.15g) or close to normal.

2. IgA Nephropathy grade 1-3, moderate mesangial proliferative nephropathy, and membranous nephropathy sensitive to immunotherapy

These kidney diseases have shown obvious pathological changes, including deposition of immune complexes, obvious cell proliferation and rete pegs formation.

Urinary protein often does not return to normal range, and 24-hour urinary protein quantitative control to 0.5g is the ideal target. In the long run, 0.5g of urinary protein has little effect on renal function.

3. IgA nephropathy grade 4-5, severe mesangial proliferative nephropathy, Focal Segmental Glomerulosclerosis (FSGS)

In this part of kidney diseases, kidney cells often appear necrosis, often insensitive to steroid therapy, and urinary protein keeps high.

Reducing the urinary protein level to less than 1 g will reduce the risk of renal function impairment and basically reach the target.

4. Membranous nephropathy

Although urinary protein over 1g can significantly impair renal function in IgA nephropathy, FSGS and other nephropathy, the harm of urinary protein in membranous nephropathy is not so great. Even if it can not be cured clinically, after treatment with "steroid + immunosuppressive agent", urinary protein can be significantly reduced to less than 4g, which also indicates that the risk of renal function damage is small and the prognosis is good.

5. Diabetic Nephropathy, Lupus Nephritis, membranoproliferative nephropathy and crescent nephritis

In most of these nephropathy, immunosuppressive agents is difficult to work, and the disease progresses faster, so don't pay too much attention to whether urinary protein can turn negative, and urinary protein can be reduced a little bit is a little success. They have many complications, and high risk of kidney failure. Lupus is even life-threatening. Comprehensive treatment is needed to control the progress of the disease. The focus of treatment is to prevent the occurrence of Kidney Failure and uremia and to ensure the safety of life.

What kind of kidney disease are you? Have you achieved your goal? For more information on proteinuria treatment, please leave a message below or contact online doctor.


***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***

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