Can CKD Patients Be Vaccinated with Hepatitis B Vaccine
Patients often ask the doctor in the course of consultation: "I have kidney disease. Can I be vaccinated with hepatitis B vaccine?” After reading this article, you will find out the answer.
According to the International KIDGO Guidelines: Risks of Chronic Kidney Disease and Infection, adults with high-risk progression of Chronic Kidney Disease (CKD) and estimated glomerular filtration rate (eGFR) of less than 30 ml/min/1.73 M2 (stage 4 - 5) should be vaccinated with hepatitis B vaccine and confirmed to be responsive by appropriate serological tests.
About IgA Nephropathy patients
IgA Nephropathy is caused by the deposition of immunoglobulin IgA in mesangial cells and mesangial areas of the kidney. Pathological conditions such as impaired cellular and humoral immune function, hypoproteinemia and poor nutritional status make patients vulnerable to infection with various pathogens. They are at high risk of hepatitis B virus infection. Injecting hepatitis B vaccine can prevent hepatitis B virus infection.
About patients at different stages of CKD patients
Patients with CKD, especially those who use immunosuppressive agents and hormones, should be careful about hepatitis B virus infection. At the same time, hepatitis B virus can cause kidney damage. Both of them will complicate clinical treatment. Therefore, it is necessary to inject hepatitis B vaccine to prevent hepatitis B virus infection. It was found that the positive conversion rate of HBsAb in patients with CKD in early and middle stages (CKD stage 1-3) was significantly higher than that in patients with CKD in late stages (CKD4-5), and the titer of HBsAb was significantly higher than that in patients with CKD4-5. therefore, early vaccination will benefit more.
About hemodialysis patients
Hemodialysis patients are at high risk of hepatitis B infection. Pre-dialysis vaccination is considered to be the most effective immune protection method to prevent infection. Clinical observation showed that there were some problems in dialysis patients, such as low serum conversion rate, low peak antibody concentration, rapid decline of antibody concentration and short maintenance time after vaccination. Therefore, it is suggested that when the titer of antibody reduces, you should strengthen immunization without waiting for complete disappearance.
Therefore, if there is no contraindication of hepatitis B vaccine, patients with chronic kidney disease can be injected with hepatitis B vaccine. For more information on CKD treatment, please leave a message below or contact online doctor.
***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***