To Lower Proteinuria And Control Creatinine, Two Methods Work Together

To Lower Proteinuria And Control Creatinine, Two Methods Work TogetherIn order to control proteinuria and stabilize renal function, it is necessary to treat kidney disease from symptoms and causes.

Symptomatic treatment

Including but not limited to the following ways:

Patients with elevated blood pressure need antihypertensive treatment

Patients with elevated blood sugar need hypoglycemic therapy

Patients with edema need diuretic treatment.

Patients with infection need anti-infective therapy.

Patients with thrombosis need anticoagulation and anti-platelet aggregation therapy

Patients with hyperlipidemia need combination of lipid-lowering drugs.

Patients with anemia need to use erythropoietin or (and) iron

Patients with severe complications of end-stage renal failure (uremia) need hemodialysis or peritoneal dialysis.

Although symptomatic treatment can not cure kidney disease, it can create a favorable environment for the treatment of kidney disease, which is the premise of kidney disease treatment, and also a means to prevent serious complications and ensure life safety.

Etiological treatment

First of all, we should clarify the etiology:

If it is secondary kidney disease, it is necessary to protect the renal function and treat the cause at the same time.

1. Hypertensive Nephropathy caused by hypertension is mainly to treat hypertension. The first choice is ACEI/ARBs.

2. Diabetic Nephropathy caused by Diabetes mellitus should be treated with metformin, repaglinide, acarbose, liraglutide and other hypoglycemic drugs that do not affect the kidney. Sulfonylureas such as glipizide, gliclazide and insulin sensitizers such as rosiglitazone should be avoided as far as possible.

3. Henoch-Schonlein Purpura Nephritis caused by Henoch-Schonlein purpura needs anti-allergic treatment.

4. Hyperuricemic nephropathy (gouty nephropathy) caused by hyperuricemia (gout) needs to be treated by inhibiting the production of uric acid or promoting the excretion of uric acid.

In the treatment of the above diseases, the kidney factors should be taken into account. Patients with severe kidney diseases should be referred to the Department of nephrology.

If it is primary kidney disease, special treatment for kidney disease is needed:

Patients with 24-hour urinary protein quantification of less than 1g receive routine supportive treatment, while patients with urinary protein of more than 1g, especially those with nephritis and Nephrotic Syndrome and proteinuria of more than 3.5g, usually use glucocorticoid and immunosuppressive drugs.

If the effect of steroids and immunosuppressive agents is not ideal, some patients can be treated by plasma exchange and targeted drugs.


As the main organ of excreting and metabolizing waste, kidney is vulnerable to many external attacks; when it is damaged, it will lead to injury of many organs in the whole body, affecting a wide range. Therefore, the treatment of kidney disease is a systematic project, which needs not only symptomatic treatment but also etiological treatment. Besides, you need to correct living habits to assist rehabilitation.


***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***

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