4 Kinds of Medications for Proteinuria Reduction and Kidney Function Protection

4 Kinds of Medications for Proteinuria Reduction and Kidney Function ProtectionBesides steroids, do you know any other medications to help you reduce proteinuria? In this article, let’s see the 4 kinds of medication for proteinuria reduction. They can also protect your renal function.

1. Leflunomide

Before leflunomide was widely used in the treatment of kidney disease, it was mainly used in the treatment of rheumatoid arthritis. As an immunosuppressant, it has anti-inflammatory effect, which helps to eliminate inflammation in kidney, and has the function of immune regulation.

At present, it has different effects on chronic nephritis, IgA Nephropathy, Membranous Nephropathy, Diabetic Nephropathy, Lupus Nephritis and other kidney disease. It can also inhibit proteinuria caused by these kidney diseases, thus protecting renal function.

Leflunomide is commonly used in combination with steroids or other immunosuppressive agents. Some patients will have nausea, vomiting, diarrhea, fatigue and other conditions. The dosage can be adjusted according to the medical condition of patients and side effects.

2. Tacrolimus

Some patients are not familiar with these drugs, which are mainly used in organ transplantation, including renal transplantation, for rejection treatment, and are widely used in the end stage of kidney disease. As a new powerful immunosuppressive agent, it is also mainly used in Nephrotic Syndrome such as Membranous Nephropathy, IgA Nephropathy, Minimal Change Disease, and Lupus Nephritis. It can inhibit inflammation and reduce the recurrence rate of proteinuria.

It is worth noting that different patients have different results after taking the medicine. It is better to monitor the blood concentration at the beginning of taking, which is more conducive to giving full play to the efficacy of drugs. At the same time, in order to avoid side effects, we should also pay attention to the examination of blood routine and other indicators.

3. Rituximab

It is targeted drug, which is mainly by eliminating the body’s B cells to avoid kidney sclerosis. As a kind of immune cell, B cells can produce antibodies themselves, which can cause pathological changes of kidney tissues and form a vicious circle. Rituximab can delay the damage of renal function by clearing B cells.

At present, it plays a prominent role in the treatment of idiopathic Membranous Nephropathy, and is also a drug with high safety in reducing proteinuria.

4. ACEI or ARBs

These two kinds of antihypertensive drugs have been developed to reduce proteinuria and protect renal function. The advantages of these two drugs in reducing proteinuria have been mentioned before.

Today let’s talk about the matters needing attention. First, patients with renal insufficiency are not recommended. These two drugs have the side effects of increasing creatinine and blood potassium. Patients with impaired renal function usually have different degrees of elevated blood pressure and high blood potassium. Therefore, patients need to monitor these two indicators when taking them. Generally, patients with creatinine elevation not exceeding 20% of the original can continue taking drugs, and patients with excessive blood potassium need to stop taking drugs. Second, pregnant women should not take it. It is harmful to the fetus and has teratogenic effect. Third, a small number of patients taking ACEI have cough. If the condition is not serious, do not stop medication. You can also reduce the amount of medication according to your condition. But do not stop medication or change medication privately.

Now you know the 4 kinds of medications for proteinuria reduction and kidney function protection. For more information on kidney disease treatment, please leave a message below or contact online doctor.


***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***

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