How to Treat Diabetic Nephropathy Effectively
The pathogenesis of Diabetic Nephropathy is very complex, which will seriously threaten the life and health of patients. People should not neglect its harm in daily life. Patients with diabetic nephropathy should pay attention to the treatment methods. What are the principles of treatment for Diabetic Nephropathy?
Principles for the treatment of diabetic nephropathy:
1. Dialysis and kidney transplantation
Once renal failure occurs, dialysis and kidney transplantation are the only effective methods. Kidney transplantation is a better way to treat diabetic uremia than dialysis. Patients over 65 years old have poor transplantation results.
2. Strict control of blood sugar
Before the occurrence of clinical diabetic nephropathy, that is, in the early stage of diabetes mellitus, strict control of diabetes mellitus with insulin pump or multiple subcutaneous injection of insulin to keep blood sugar basically normal can delay or even prevent the occurrence and development of diabetic nephropathy, reduce the increased glomerular filtration rate and improve microalbuminuria. It is also beneficial to other complications.
According to the study of DCCT, the risk of diabetic nephropathy was reduced by 35%-55% when T1DM was intensively treated with insulin. It has developed into clinical diabetic nephropathy with obvious proteinuria. Controlling blood sugar is less helpful to the development of diabetic nephropathy. In general, insulin should be used as a hypoglycemic drug after clinical diabetic nephropathy.
3. Controlling hypertension
Hypertension can promote the development of renal failure. Effective antihypertensive therapy can slow down the decline of glomerular filtration rate and reduce urinary albumin excretion.
Angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists can be used as the preferred drugs, often in combination with other antihypertensive drugs, such as calcium antagonists, diuretics, beta blockers, methyldopa and clonidine.
Diabetic patients with blood pressure ≥ 130/80mmHg should be treated with antihypertensive drugs, which should be controlled below 130/80mmHg. When treated with antihypertensive drugs, relatively healthy glomeruli continue to survive due to decreased glomerular capillary pressure, and the damaged glomeruli quickly become completely blocked, water can not be filtered, and protein can not leak out.
It was observed that when blood pressure dropped from 160/95 mmHg to 135/85-mmHg, urinary protein excretion decreased significantly and glomerular filtration rate decreased from lml/min per month to 0.35 ml/min per month. The survival time of patients with diabetic nephropathy was also significantly prolonged. The cumulative mortality rate was 50% - 70% in 10 years before antihypertensive therapy and 18% after antihypertensive therapy. Antihypertensive therapy is also beneficial for diabetic retinopathy.
4. Restricting protein intake
Appropriate reduction of protein content in diet (0.8/kg.d) can reduce intraglomerular pressure, alleviate hyperfiltration and reduce proteinuria. On the contrary, high protein diet can aggravate glomerular histological lesions. People with renal insufficiency should limit protein intake and eat proteins with high essential amino acids.
5. Pancreatic tissue repair therapy
Pancreatic factor infiltration plays an important role in tissue and organ repair and regeneration induced by diabetes mellitus, congenital pancreatic malformation, pancreatic injury, acute and chronic pancreatitis, etc. Diabetes mellitus is caused by selective destruction of insulin-producing beta cells. Through the induction and infiltration of pancreatic factors to compensate for the loss of beta cells and to provide the required amount of insulin so that the symptoms of diabetic patients can be controlled to a large extent. Pancreatic factor infiltration is one of the most effective methods to treat diabetes mellitus. The greatest attraction is to repair islet beta cells by inducing and infiltrating pancreatic factor in order to cure diabetes successfully clinically.
In conclusion, people should pay attention to the harm of diabetic nephropathy. Diabetic nephropathy patients should find out suitable methods and follow the advice of doctors so as not to make the condition worse. For more information on Diabetic Nephropathy treatment, please leave a message below or contact online doctor.
***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***