Why Does Nephrotic Syndrome Causes Massive Proteinuria
The water and solutes in the blood are filtered into the renal follicle through the glomeruli to form the urine, which must pass through the endothelial cells, basement membrane and epithelial cells of the capillary wall. This three-layer structure is called the glomerular filtration membrane.
The three filtration membrane all have certain pores, which can only allow certain molecular weight and molecular diameter materials pass through, and thus constitute the pore size barrier of the filter membrane. The surface of the three layers is covered with sialic acid protein. The glomerular basement membrane and outer tectorium is rich in heparin sulfate. These substances have a negative charge in the body fluid environment, repelling the negative charge of the solute passing through so as to form the charge barrier of the filter membrane.
Besides, the glomerular mesangium between the glomerular capillaries has a regulatory effect on the glomerular filtration barrier, and thus has a certain impact on the glomerular filtration.
Under normal circumstances, most protein in the blood can not pass through the glomerular filtration barrier. Especially, macromolecules and negatively charged albumin can hardly pass through. A few micromolecules passing through the membrane can be reabsorbed in the renal tubules.
Therefore, about 10-15kg plasma protein flows through the kidney every day, less than 150mg of protein is excreted from the urine. In Nephrotic Syndrome, due to various pathological factors, the barrier function of filtration membrane is damaged like increased pore size or reduced negative charge, resulting in massive protein leakage, which is far beyond the resorption capacity of renal tubule. Then, massive proteinuria occurs.
Here we recommend systematic Chinese Medicine Treatment including Micro-Chinese Medicine Osmotherapy, Medicated Bath, Medicated Foot Bath, Medicinal Soup, Moxibustion Therapy and Steaming Therapy, etc. When the patient comes to our hospital, we first test the patient and then our experts will make a treatment plan based on the illness condition. Chinese medicines first purify your blood through removing toxins and wastes from the body to give you a clean blood environment. In this clean body environment, Chinese medicines can arrive at kidney lesion directly to repair filtration membrane and improve renal function through expanding blood vessels, improving blood circulation, preventing inflammation and coagulation, degrading extracellular matrix and providing nutrients. When injured filtration membrane is restored, massive proteinuria can be stopped. No relapse occurs.
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***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***